This brief 2013 review summarizes two studies investigating the metabolic impact of fructose overconsumption, placing them in the broader context of the scientific literature. The authors note that “diets high in fructose could cause excess fat accumulation in the liver, leading to ... fatty liver disease, steatohepatitis and, ultimately, cirrhosis. Liver fat could also be released into the circulation and taken up by fat cells in other tissues, resulting in obesity. Furthermore, the circulating fat could accelerate the onset of cardiovascular disease, insulin resistance and type 2 diabetes. So fructose over-consumption may be at the heart of metabolic syndrome, which has also been linked to poor outcome of a wide range of cancers.”