Evidence-based medicine (EBM) has been described as “the conscientious, explicit and judicious use of current best evidence in helping individual patients make decisions about their care in the light of their personal values and beliefs.” Unfortunately, according to Dr. Malcolm Kendrick, the unquestioned dominance of EBM in medical practice has, in many cases, created more problems than it has solved. In this three-part series, Kendrick discusses various reasons for the ineffectiveness of EBM. Here, he discusses how the widespread influence of the pharmaceutical industry over research priorities produces research that is more profitable than helpful, leading to problems such as the antibiotic resistance crisis.