Michael Eades, MD, revisits a seminal study from 1992 by Samuel Klein and Robert Wolfe on the metabolic effects of carbohydrate restriction and fasting. Klein and Wolfe determined their results “demonstrate that restriction of dietary carbohydrate, not the general absence of energy intake itself, is of fundamental importance in the adaptive response to short-term fasting” and claimed their study “underscores the importance of carbohydrate intake for normal fuel homeostasis."