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Impact of Metformin on Exercise-induced metabolic adaptations to lower type 2 diabetes risk

Both exercise and metformin have been shown to independently improve glycemic control and insulin sensitivity in diabetics; the former has also been shown to drive cardiovascular improvements. This 2016 review finds that metformin impairs muscular adaptation to exercise across multiple dimensions, including the primary mechanism by which muscle cells increase aerobic and metabolic function in response to exercise. Metformin thus may counteract the beneficial effects of exercise in diabetics.

Read MoreImpact of Metformin on Exercise-induced metabolic adaptations to lower type 2 diabetes risk