This 2018 review examines the experimental and clinical evidence that fructose precipitates fat accumulation in the liver. The authors explain, “Non-alcoholic fatty liver disease is the hepatic manifestation of metabolic syndrome; its rising prevalence parallels the rise in obesity and diabetes. Historically thought to result from overnutrition and a sedentary lifestyle, recent evidence suggests that diets high in sugar (from sucrose and/or high-fructose corn syrup) not only increase the risk of NAFLD but also non-alcoholic steatohepatitis.”